Serum total LDH activity and LDH-2 isozyme in nephrotic syndrome.

Proteinuria, hypoproteinaemia, hypoalbuminaemia and oedema are major characteristics of nephrotic syndrome. Aims of this study were to detect serum total LDH activity and its isozymes in nephrotic syndrome. In a cross-sectional study, clinical parameters were compared in three cohorts, namely kidney patients with or without nephrotic syndrome and hypoalbuminaemic controls (NEPHR, NON-NEPHR, CONTR, respectively). Serum total LDH activity in the NEPHR group was increased compared with the NON-NEPHR and CONTR groups (p < 0.001) and correlated with serum total protein (r = -0.549, p < 0.001), serum albumin (r = -0.596, p < 0.001), proteinuria (r = 0.456, p < 0.001) and serum total cholesterol (r = 0.523, p < 0.001). LDH isozyme pattern was analysed in three subgroups of the patients. Serum LDH-2 activity was higher in the NEPHR subgroup compared with the NON-NEPHR and CONTR subgroups (p < 0.001). Serum LDH-2 activity correlated with serum total protein (r = -0.665, p < 0.001), serum albumin (r = -0.615, p < 0.001), proteinuria (r = 0.694, p < 0.001), and serum total cholesterol (r = 0.723, p < 0.001). Linear regression analysis revealed that serum total protein proved to be an independent predictor of serum total LDH activity, while serum total protein and proteinuria were predictors of LDH-2. These findings suggest that serum total LDH activity might be a marker of the activity of the nephrotic syndrome. (c) 2008 S. Karger AG, Basel

Citation

Márton Mohás, Nóra Szigeti, Lajos Markó, Gergo A Molnár, Judit Cseh, Boglárka Laczy, Mónika Tamaskó, József Balla, János Kappelmayer, László Wagner, Zoltán Wagner, Botond Csiky, Judit Nagy, István Wittmann. Serum total LDH activity and LDH-2 isozyme in nephrotic syndrome. Kidney & blood pressure research. 2008;31(1):47-54

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PMID: 18185017

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