Evidence for association of chromosome 10 open reading frame (C10orf27) gene polymorphisms and multiple sclerosis.

Robert Goertsches, Sergio E Baranzini, Carlos Morcillo, Carlos Nos, Montse Camiña, Jorge R Oksenberg, Xavier Montalban, Manuel Comabella

Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron (HUVH), 08035 Barcelona, Spain. robert.goertsches@med.uni-rostock.de

Multiple sclerosis (Houndmills, Basingstoke, England) 2008 Apr

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A recent association study has provided evidence that chromosome 10q22.1 may contain candidate genes for multiple sclerosis (MS). We analysed two intronic and a non-synonymous single nucleotide polymorphism (SNP) of the C10orf27 gene in 571 patients with MS (relapsing remitting and primary progressive) and healthy controls. Adjusted comparisons revealed significant association with disease susceptibility for one intronic SNP in RRMS individuals and the amino acid modifying SNP for PPMS cases; the latter may also contribute to faster disease progression. Transcript expression in brain lesions from MS patients was increased. These findings suggest C10orf27 as a candidate gene for MS susceptibility and pathogenesis.

Citation

Robert Goertsches, Sergio E Baranzini, Carlos Morcillo, Carlos Nos, Montse Camiña, Jorge R Oksenberg, Xavier Montalban, Manuel Comabella. Evidence for association of chromosome 10 open reading frame (C10orf27) gene polymorphisms and multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England). 2008 Apr;14(3):412-4