Anti-inflammatory and analgesic activities of newly synthesized chiral peptide derivatives using (3-benzoyl- 4,5-dioxo-2-phenyl-pyrrolidin-1-yl)acetic acid ethyl ester as starting material.

Issa M Fakhr, Abdel-Galil E Amr, Nermien M Sabry, Mohamed M Abdalah

Applied Organic Chemistry Department, National Research Center, Dokki, Cairo, Egypt.

Archiv der Pharmazie 2008 Mar

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A series of heterocyclic derivatives was synthesized using (3-benzoyl-4,5-dioxo-2-phenyl-pyrrolidin-1-yl)acetic acid ethyl ester 1 as starting material. Treatment of 1 with 1 N NaOH or hydrazine hydrate afford the corresponding acid 2 and acid hydrazides 4 and 5, which were reacted with several reagents to produce some new peptido hetero-organic derivatives 6-12. The pharmacological screening showed that many of these newly synthesized compounds have good anti-inflammatory and analgesic activities comparable to diclofenac potassium and valdecoxib as reference drugs.

Citation

Issa M Fakhr, Abdel-Galil E Amr, Nermien M Sabry, Mohamed M Abdalah. Anti-inflammatory and analgesic activities of newly synthesized chiral peptide derivatives using (3-benzoyl- 4,5-dioxo-2-phenyl-pyrrolidin-1-yl)acetic acid ethyl ester as starting material. Archiv der Pharmazie. 2008 Mar;341(3):174-80