Aurora B kinases restrict chromosome decondensation to telophase of mitosis.

Department of Genetics, Cell Biology & Development, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.

Cell cycle (Georgetown, Tex.) 2008 Feb 1

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The Aurora kinases comprise a family of evolutionary conserved serine/threonine kinases that have important functions in centrosome duplication, mitotic spindle assembly, chromosome condensation, chromosome biorientation on the spindle and chromosome segregation. Vertebrates have three Aurora kinases, Aurora-A, -B and -C, while invertebrates have only Aurora-A and -B and yeasts have a single Aurora kinase, IpI1 in S. cerevisiae and Ark1 in S. pombe. Recently, the role of Aurora kinases in chromosome condensation has been defined; Aurora B plays a crucial role in the axial shortening of chromosomes during anaphase, presumably in order to prevent chromosome arms from becoming trapped within the cytokinetic plate.

Citation

Amit Cj Vas, Duncan J Clarke. Aurora B kinases restrict chromosome decondensation to telophase of mitosis. Cell cycle (Georgetown, Tex.). 2008 Feb 1;7(3):293-6