Withangulatin I, a new cytotoxic withanolide from Physalis angulata.

Shwu-Woan Lee, Min-Hsiung Pan, Chiu-Ming Chen, Zong-Tsi Chen

Department of Applied Chemistry, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan, ROC.

Chemical & pharmaceutical bulletin 2008 Feb

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A new withanolide, withangulatin I (2), was isolated from the whole plant of Physalis angulata. Its structure was established as (20S,22R)-15alpha-acetoxy-5beta,6beta-epoxy-14alpha-hydroxy-1,4-dioxo-witha-2,16,24-trienolide on the basis of chemical and spectroscopic methods including 2D-NMR and circular dichroism (CD) experiments. Withangulatin A (1) and withangulatin I (2) were tested for their cytotoxic activities against two human cancer cell lines, colorectal carcinoma COLO 205 and gastric carcinoma AGS, in vitro. Compounds 1 and 2 exhibited inhibitory activities against these two human cancer cells with IC(50) values of 16.6 and 1.8 and 53.6 and 65.4 muM, respectively.

Citation

Shwu-Woan Lee, Min-Hsiung Pan, Chiu-Ming Chen, Zong-Tsi Chen. Withangulatin I, a new cytotoxic withanolide from Physalis angulata. Chemical & pharmaceutical bulletin. 2008 Feb;56(2):234-6