Alpha1-adrenoceptor subtypes and lower urinary tract symptoms.

Debra A Schwinn, Claus G Roehrborn

International journal of urology : official journal of the Japanese Urological Association 2008 Mar

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Benign prostatic hyperplasia (BPH) is a common cause of urinary outflow obstruction in aging men leading to lower urinary tract symptoms (LUTS). alpha(1)-Adrenoceptors (alpha(1)ARs) antagonists (blockers) have become a mainstay of LUTS treatment because they relax prostate smooth muscle and decrease urethral resistance, as well as relieving bladder LUTS symptoms. A review of key recent clinical trials suggests new insights into the role of specific alpha(1)AR subtypes in the treatment of LUTS.

Citation

Debra A Schwinn, Claus G Roehrborn. Alpha1-adrenoceptor subtypes and lower urinary tract symptoms. International journal of urology : official journal of the Japanese Urological Association. 2008 Mar;15(3):193-9