Mouse organic anion transporter 2 (mOat2) mediates the transport of short chain fatty acid propionate.

Rafiqul Islam, Naohiko Anzai, Nesar Ahmed, Babu Ellapan, Chun Ji Jin, Sunena Srivastava, Daisaku Miura, Toshiyuki Fukutomi, Yoshikatsu Kanai, Hitoshi Endou

Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan.

Journal of pharmacological sciences 2008 Mar

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In this study, we have elucidated that propionate, one of the short chain fatty acids (SCFAs), is the transport substrate for murine organic anion transporter 2 (mOat2), which is expressed in the kidneys and the liver. When expressed in Xenopus oocytes, mOat2-mediated [(3)H]PGE(2) transport was inhibited by three- to five-carbon SCFAs (C3 to C5). Among the SCFAs tested, propionate (3-carbon SCFA) was transported by mOat2 in a time-dependent manner. Since propionate is a potent glucogenic compound, Oat2 may be involved in the regulation of cellular metabolism through the transport of these metabolites in the kidneys and the liver.

Citation

Rafiqul Islam, Naohiko Anzai, Nesar Ahmed, Babu Ellapan, Chun Ji Jin, Sunena Srivastava, Daisaku Miura, Toshiyuki Fukutomi, Yoshikatsu Kanai, Hitoshi Endou. Mouse organic anion transporter 2 (mOat2) mediates the transport of short chain fatty acid propionate. Journal of pharmacological sciences. 2008 Mar;106(3):525-8