Structural features of the Cu(II) complex with the rat Abeta(1-28) fragment.

Elena Gaggelli, Zbigniew Grzonka, Henryk Kozłowski, Caterina Migliorini, Elena Molteni, Daniela Valensin, Gianni Valensin

Department of Chemistry, University of Siena, via Aldo Moro, 53100 Siena, Italy.

Chemical communications (Cambridge, England) 2008 Jan 21

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The interaction between Cu(II) and the rat amyloid beta (1-28) fragment in micellar solutions at pH 7.5 was investigated by CD and NMR spectroscopy; the proton-copper distances were used in restrained molecular dynamics simulations to obtain a structural model of the Cu(II) complex.

Citation

Elena Gaggelli, Zbigniew Grzonka, Henryk Kozłowski, Caterina Migliorini, Elena Molteni, Daniela Valensin, Gianni Valensin. Structural features of the Cu(II) complex with the rat Abeta(1-28) fragment. Chemical communications (Cambridge, England). 2008 Jan 21(3):341-3