Synthesis of fluorinated nucleosides.

Satoshi Katayama, Satoshi Takamatsu, Naoko Hirose, Kunisuke Izawa, Tokumi Maruyama

AminoScience Laboratories, Ajinomoto Co., Kanagawa, Japan.

Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2006 Jul

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Two practical synthetic approaches to the production of lodenosine [FddA, 9-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl)adenine] via 6-chloropurine riboside or 6-chloropurine 3'-deoxyriboside are described. The reaction sequence contains new fluorination methods and new applications of radical reduction. The reagents and reaction conditions of each step have been carefully selected to ensure robustness and safety.

Citation

Satoshi Katayama, Satoshi Takamatsu, Naoko Hirose, Kunisuke Izawa, Tokumi Maruyama. Synthesis of fluorinated nucleosides. Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.]. 2006 Jul;Chapter 1:Unit 1.12