Screening of a Saccharomyces cerevisiae nonessential gene deletion collection for altered susceptibility to a killer peptide.

Stefania Conti, Walter Magliani, Laura Giovati, Irene Libri, Domenico Leonardo Maffei, Antonella Salati, Luciano Polonelli

Dipartimento di Patologia e Medicina di Laboratorio, Sezione di Microbiologia, University of Parma, Parma, Italy.

The new microbiologica 2008 Jan

filter terms:

Approximately 4,800 Saccharomyces cerevisiae mutants deleted for nonessential genes were screened for alterations in susceptibility to a synthetic killer peptide (KP). None of the tested strains, including mutants resistant to conventional antifungal drugs, showed increased or decreased susceptibility to KP in comparison with the parental strain. The results may reflect the peculiar mechanism of action of KP and claim the possible avoidance of vital resistant mutants.

Citation

Stefania Conti, Walter Magliani, Laura Giovati, Irene Libri, Domenico Leonardo Maffei, Antonella Salati, Luciano Polonelli. Screening of a Saccharomyces cerevisiae nonessential gene deletion collection for altered susceptibility to a killer peptide. The new microbiologica. 2008 Jan;31(1):143-5