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Type 3 deiodinase in hypoxia: to cool or to kill?
Sabrina Diano, Tamas L Horvath
Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA. sabrina.diano@yale.edu
Cell metabolism 2008 MaySizes of these terms reflect their relevance to your search.
Type 3 deiodinase (D3) inactivates thyroid hormones. Simonides et al. (2008) now report that hypoxia-induced D3 activation leads to reduction of 3,5,3'-triiodothyronine (T3) and oxygen consumption, suggesting that D3 activation is a component of cellular responses to hypoxia and supporting the idea of cell-specific regulation of thyroid hormone levels by deiodinases.
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Sabrina Diano, Tamas L Horvath. Type 3 deiodinase in hypoxia: to cool or to kill? Cell metabolism. 2008 May;7(5):363-4
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PMID: 18460327
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