Synthesis and radioprotective activity of new organosilicon and germanium compounds.

Silathiazolidine and metalladithioacetals (M = Si, Ge) have been prepared by the interaction of dialkyldichloro- or bis(diethylamino)dialkylsilanes and -germanes with 3-[N-(2- thioethyl)]amino-propanamide (WR-2529) and [1-thioethyl-2-(1-naphtylmethyl)]-2- imidazoline. The study of these compounds in the field of chemical radioprotection has shown a notable decrease in the toxicity and a rather large increase in the radioprotective activity of these new derivatives in comparison with the starting organic compounds.

Citation

G Rima, J Satgé, R Dagiral, C Lion, M Fatome, V Roman, J D Laval. Synthesis and radioprotective activity of new organosilicon and germanium compounds. Metal-based drugs. 1998;5(3):139-46

PMID: 18475835

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