A new homostilbene and two new homoisoflavones from the bulbs of Scilla scilloides.

Yoichiro Nishida, Masashi Eto, Hiroyuki Miyashita, Tsuyoshi Ikeda, Koki Yamaguchi, Hitoshi Yoshimitsu, Toshihiro Nohara, Masateru Ono

Aso Pharmaceutical Co Ltd, Kumamoto, Japan.

Chemical & pharmaceutical bulletin 2008 Jul

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A new homostilbene, named scillabene A (2), and two new homoisoflavones, named scillavones A (3) and B (4), were isolated from the bulbs of Scilla scilloides DRUCE (Liliaceae) along with 13 known compounds comprising a homostilbene, seven homoisoflavones, a xanthone, a lignan, and three nortriterpenes. The structures of 2-4 were characterized as 3,5,4'-trihydroxy-3'-methoxy-4-methyl-trans-stilbene, (3R)-5,7,2'-trihydroxy-3',4'-dimethoxyspiro{2H-1-benzopyran-7'-bicyclo[4,2,0]octa[1,3,5]-trien}-4-one and (3S)-3-(3,4-dihydroxybenzyl)-5-hydroxy-6,7-dimethoxychroman-4-one, respectively, on the basis of spectroscopic data and X-ray crystallographic analysis.

Citation

Yoichiro Nishida, Masashi Eto, Hiroyuki Miyashita, Tsuyoshi Ikeda, Koki Yamaguchi, Hitoshi Yoshimitsu, Toshihiro Nohara, Masateru Ono. A new homostilbene and two new homoisoflavones from the bulbs of Scilla scilloides. Chemical & pharmaceutical bulletin. 2008 Jul;56(7):1022-5