Urate transport across the apical membrane of renal proximal tubules.

Hitoshi Endou, Naohiko Anzai

Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan. endouh@kyorin-u.ac.jp

Nucleosides, nucleotides & nucleic acids 2008 Jun

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Since the molecular cloning of the renal apical urate/anion exchanger URAT1 (SLC22A12), several membrane proteins relevant to urate transport have been identified. In addition, the identification of PDZ (PSD-95, DglA, and ZO-1) domain protein PDZK1 as a binding partner of URAT1, and the emerging role of PDZ scaffold for renal apical transporters have led to a new concept of renal urate transport: urate-transporting multimolecular complex, or "urate transportsome," that may form an ultimate functional unit at the apical membrane of renal proximal tubules. Elucidation of urate transportsome will lead to the new drug development for hyperuricemia.

Citation

Hitoshi Endou, Naohiko Anzai. Urate transport across the apical membrane of renal proximal tubules. Nucleosides, nucleotides & nucleic acids. 2008 Jun;27(6):578-84