Highly chemoselective reduction of aromatic nitro compounds by copper nanoparticles/ammonium formate.

A highly chemoselective reduction of aromatic nitro compounds to the corresponding amino derivatives has been achieved by a combination of copper nanoparticles and ammonium formate in ethylene glycol at 120 degrees C. The reductions are successfully carried out in presence of a wide variety of other reducible functional groups in the molecule, such as Cl, I, OCH2Ph, NHCH2Ph, COR, COOR, CN, etc. The reactions are very clean and high yielding.

Citation

Amit Saha, Brindaban Ranu. Highly chemoselective reduction of aromatic nitro compounds by copper nanoparticles/ammonium formate. The Journal of organic chemistry. 2008 Sep 5;73(17):6867-70

PMID: 18656983

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