Tolevamer, an orally administered, toxin-binding polymer for Clostridium difficile-associated diarrhea.

Columbia University School of Medicine, St Luke's-Roosevelt Hospital Center, 10th Ave and 59th St, New York, NY 10025, USA. Scheinfeld@earthlink.net

Current opinion in investigational drugs (London, England : 2000) 2008 Aug

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Genzyme Corp is developing tolevamer, an anionic toxin-binding polymer that binds and neutralizes the Clostridium difficile A and B toxins, for the potential treatment of C difficile-associated diarrhea (CDAD). Two phase III clinical trials of tolevamer in patients with CDAD have been completed and results from the second trial are expected to be released imminently.

Citation

Noah Scheinfeld, Kristen Biggers. Tolevamer, an orally administered, toxin-binding polymer for Clostridium difficile-associated diarrhea. Current opinion in investigational drugs (London, England : 2000). 2008 Aug;9(8):913-24