Cembrane diterpenes from the gorgonian Leptogorgia laxa.

María J Ortega, Eva Zubía, M Carmen Sánchez, J Luis Carballo

Departamento de Química Orgánica, Facultad de Ciencias del Mar y Ambientales, Universidad de Cádiz, Apartado 40, 11510-Puerto Real (Cádiz), Spain.

Journal of natural products 2008 Sep

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The new cembrane diterpenes leptodienone A (2) and leptodienone B (3) and the known compounds lopholide, lophodiol B, lophodione, and lophotoxin (1) have been isolated from the gorgonian Leptogorgia laxa collected in the Gulf of California. The structures of the new metabolites have been established by spectroscopic techniques. The in vitro cytotoxicity of the new compounds has been tested against three human tumor cell lines.

Citation

María J Ortega, Eva Zubía, M Carmen Sánchez, J Luis Carballo. Cembrane diterpenes from the gorgonian Leptogorgia laxa. Journal of natural products. 2008 Sep;71(9):1637-9