A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes.

We report a previously uncharacterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors. We show that this domain behaves as an independent folding unit and that it stoichiometrically binds zinc in a one-to-one ratio. Based on the conserved sequence features we predict that this domain may function as a RNA recognition and binding module.

Citation

Antonina Andreeva, Henning Tidow. A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes. Bioinformatics (Oxford, England). 2008 Oct 15;24(20):2277-80

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PMID: 18703587

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