Synthesis and anti-CVB 3 evaluation of substituted 5-nitro-2-phenoxybenzonitriles.

Gerhard Pürstinger, Armando M De Palma, Günther Zimmerhofer, Simone Huber, Sophie Ladurner, Johan Neyts

Institut für Pharmazie, Abteilung Pharmazeutische Chemie, Universität Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria. Gerhard.Puerstinger@uibk.ac.at

Bioorganic & medicinal chemistry letters 2008 Sep 15

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The synthesis and SAR of a series of 60 substituted 2-phenoxy-5-nitrobenzonitriles (analogues of MDL-860) as inhibitors of enterovirus replication (in particular of coxsackievirus B3 (CVB 3)) are reported. Several of the analogues inhibited CVB 3 and other enteroviruses at low-micromolar concentrations.

Citation

Gerhard Pürstinger, Armando M De Palma, Günther Zimmerhofer, Simone Huber, Sophie Ladurner, Johan Neyts. Synthesis and anti-CVB 3 evaluation of substituted 5-nitro-2-phenoxybenzonitriles. Bioorganic & medicinal chemistry letters. 2008 Sep 15;18(18):5123-5