The morphofunctional characteristics of proteins of nucleolar organizers in uterine smooth muscle tumors].

I P Bobrov, A M Avdalian, A F Lazarev, V V Klimachev, T B Klimacheva, E V Mishchenko

Arkhiv patologii 2008 May-Jun

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The authors have shown the activity of argyrophylic nucleolar organizer region proteins (Ag-NOR-proteins) in the uterine leiomyomas of varying histological structure and determined their relationship to the growth rate, size, and site of a node and endometrial pathology. The investigation indicat yomas with significant sclerosis, 4.32 +/- 0.1 in simple leiomyomas, and 6.2 +/- 0.2 in cell leiomyomas (r = 0.58). In menopause, myomas with significant sclerosis and hyalinosis were characterized with a small number of Ag-NOR (1.44 +/- 0.04). Thus, the organizers numbered 12.1 +/- 0.5 and 21.7 +/- 1.0 in high- and low-grade sarcomas, respectively, which may be used in the differential diagnosis of cellular, bizarre, mitotically active leiomyomas and leiomyosarcomas.

Citation

I P Bobrov, A M Avdalian, A F Lazarev, V V Klimachev, T B Klimacheva, E V Mishchenko. The morphofunctional characteristics of proteins of nucleolar organizers in uterine smooth muscle tumors]. Arkhiv patologii. 2008 May-Jun;70(3):18-23