Inteferons pen the JAK-STAT pathway.

Characterization of how interferons (IFNs) mediate their biological response led to identification of the JAK-STAT signaling cascade, where JAKs are receptor-associated kinases and STATs the transcription factors they activate. Today, 4 JAKs and 7 STATs are known to transduce pivotal signals for the over 50 members of the four-helix bundle family of cytokines. This review will provide an overview and historical perspective of the JAK-STAT paradigm.

Citation

Christian Schindler, Courtney Plumlee. Inteferons pen the JAK-STAT pathway. Seminars in cell & developmental biology. 2008 Aug;19(4):311-8

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PMID: 18765289

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