Non-cannabinoid constituents from a high potency Cannabis sativa variety.

Mohamed M Radwan, Mahmoud A Elsohly, Desmond Slade, Safwat A Ahmed, Lisa Wilson, Abir T El-Alfy, Ikhlas A Khan, Samir A Ross

Phytochemistry 2008 Oct

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Six new non-cannabinoid constituents were isolated from a high potency Cannabis sativa L. variety, namely 5-acetoxy-6-geranyl-3-n-pentyl-1,4-benzoquinone (1), 4,5-dihydroxy-2,3,6-trimethoxy-9,10-dihydrophenanthrene (2), 4-hydroxy-2,3,6,7-tetramethoxy-9,10-dihydrophenanthrene (3), 4,7-dimethoxy-1,2,5-trihydroxyphenanthrene (4), cannflavin C (5) and beta-sitosteryl-3-O-beta-d-glucopyranoside-2'-O-palmitate (6). In addition, five known compounds, alpha-cannabispiranol (7), chrysoeriol (8), 6-prenylapigenin (9), cannflavin A (10) and beta-acetyl cannabispiranol (11) were identified, with 8 and 9 being reported for the first time from cannabis. Some isolates displayed weak to strong antimicrobial, antileishmanial, antimalarial and anti-oxidant activities. Compounds 2-4 were inactive as analgesics.

Citation

Mohamed M Radwan, Mahmoud A Elsohly, Desmond Slade, Safwat A Ahmed, Lisa Wilson, Abir T El-Alfy, Ikhlas A Khan, Samir A Ross. Non-cannabinoid constituents from a high potency Cannabis sativa variety. Phytochemistry. 2008 Oct;69(14):2627-33