Frajunolides E-K, briarane diterpenes from Junceella fragilis.

Chia-Ching Liaw, Ya-Ching Shen, Yun-Sheng Lin, Tsong-Long Hwang, Yao-Haur Kuo, Ashraf Taha Khalil

Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China.

Journal of natural products 2008 Sep

filter terms:

Chemical investigation of the gorgonian octocoral Junceella fragilis, collected in Taiwan, resulted in the isolation of seven new briarane-type diterpenes, frajunolides E-K (1-7), in addition to 14 known briaranes, praelolide, junceellin, junceellolides A-E, and K, 11a,20a-epoxy-4-deacetoxyjunceelolide D, umbraculolide A, junceellonoid A, and juncins Y, Z, and ZI, as well as ergosterol peroxide. The structures of 1-7 were determined by analysis of HRESIMS and 2D NMR spectroscopic data. Cytotoxicity and in vitro anti-inflammatory activities of compounds 1-7 were also evaluated.

Citation

Chia-Ching Liaw, Ya-Ching Shen, Yun-Sheng Lin, Tsong-Long Hwang, Yao-Haur Kuo, Ashraf Taha Khalil. Frajunolides E-K, briarane diterpenes from Junceella fragilis. Journal of natural products. 2008 Sep;71(9):1551-6