PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion.
Sebastian Seufert, Roland Coras, Christian Tränkle, Darius P Zlotos, Ingmar Blümcke, Lars Tatenhorst, Michael T Heneka, Eric Hahnen
Institute of Human Genetics, Institute of Genetics, and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Street 34, 50931 Cologne, Germany.
PPAR research 2008Today, there is increasing evidence that PPARgamma agonists, including thiazolidinediones (TDZs) and nonthiazolidinediones, block the motility and invasiveness of glioma cells and other highly migratory tumor entities. However, the mechanism(s) by which PPARgamma activators mediate their antimigratory and anti-invasive properties remains elusive. This letter gives a short review on the debate and adds to the current knowledge by applying a PPARgamma inactive derivative of the TDZ troglitazone (Rezulin) which potently counteracts experimental glioma progression in a PPARgamma independent manner.
Citation
Sebastian Seufert, Roland Coras, Christian Tränkle, Darius P Zlotos, Ingmar Blümcke, Lars Tatenhorst, Michael T Heneka, Eric Hahnen. PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion. PPAR research. 2008;2008:513943
PMID: 18815619
View Free Full Text
