Ru3(CO)12-catalyzed reactions of catechols with alkynes: an atom-economic process for the synthesis of 2,2-disubstituted 1,3-benzodioxoles from the double addition of the O-H bond across a triple bond.
Department of Chemistry, Tsinghua University, Innovative Catalysis Program, Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Beijing 100084, China.
The Journal of organic chemistry 2008 Nov 7Ru3(CO)12 has been found to be the efficient catalyst for the addition reactions of catechols with both terminal and internal alkynes to selectively afford 2,2-disubstituted 1,3-benzodioxoles in good to high yields. The formation of 2,2-substituted 1,3-benzodioxoles results from the tandem addition of two O-H bonds of catechols to alkyne's triple bond.
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Ming Li, Ruimao Hua. Ru3(CO)12-catalyzed reactions of catechols with alkynes: an atom-economic process for the synthesis of 2,2-disubstituted 1,3-benzodioxoles from the double addition of the O-H bond across a triple bond. The Journal of organic chemistry. 2008 Nov 7;73(21):8658-60
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PMID: 18817449
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