Electroreduction and determination of Pipril (Piperacillin) in both aqueous and biological samples.

The electrochemical behavior of the relatively new antibacterial antibiotic Pipril (Piperacillin) at the dropping mercury electrode is investigated using both direct current polarography (DCP) and differential pulse polarography (DPP). At the hanging mercury electrode (HMDE), the reduction mechanism has been elucidated using cyclic voltammetric technique in the pH range from 2 to 10. The effect of some metal ions, e.g. Cu(II) and Pb(II) has been also tested. Determination of the drug using adsorptive stripping analysis was assessed in both aqueous and urine samples. The effect of the different experimental parameters affecting the drug determination, e.g. pH, supporting electrolyte nature, accumulation potential, accumulation time and other operational parameters are also mentioned. Detection limits of 5 x 10(-9) and 1 x 10(-8)M Pipril in aqueous and urine samples, respectively, are achieved.

Citation

N A El-Maali, M A Ghandour, M Khodari. Electroreduction and determination of Pipril (Piperacillin) in both aqueous and biological samples. Talanta. 1993 Dec;40(12):1833-8

PMID: 18965859

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