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A mild synthetic method for N-formyl-Met-Leu-Phe-OH (1) is described. After Fmoc solid phase peptide synthesis, on-bead formylation and HPLC purification, more than 30 mg of the fully (13)C/(15)N-labelled tripeptide 1 could be isolated in a typical batch. This peptide can be easily crystallised and is therefore well suited as a standard sample for setting up solid-state NMR experiments.


Sven T Breitung, Jakob J Lopez, Gerd Dürner, Clemens Glaubitz, Michael W Göbel, Marcel Suhartono. A practical synthesis of the 16C/15N-labelled tripeptide N-formyl-Met-Leu-Phe, useful as a reference in solid-state NMR spectroscopy. Beilstein journal of organic chemistry. 2008;4:35

PMID: 18982075

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