p120-Ras GTPase activating protein (RasGAP): a multi-interacting protein in downstream signaling.

Perayot Pamonsinlapatham, Réda Hadj-Slimane, Yves Lepelletier, Barbara Allain, Mirco Toccafondi, Christiane Garbay, Françoise Raynaud

Université Paris Descartes, UFR Biomédicale, Laboratoire de Pharmacochimie Moléculaire et Cellulaire, 45 Rue des Saints-Pères, 75270 Paris Cedex 06, France.

Biochimie 2009 Mar

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p120-RasGAP (Ras GTPase activating protein) plays a key role in the regulation of Ras-GTP bound by promoting GTP hydrolysis via its C-terminal catalytic domain. The p120-RasGAP N-terminal part contains two SH2, SH3, PH (pleckstrin homology) and CaLB/C2 (calcium-dependent phospholipid-binding domain) domains. These protein domains allow various functions, such as anti-/pro-apoptosis, proliferation and also cell migration depending of their distinct partners. The p120-RasGAP domain participates in protein-protein interactions with Akt, Aurora or RhoGAP to regulate functions described bellow. Here, we summarize, in angiogenesis and cancer, the various functional roles played by p120-RasGAP domains and their effector partners in downstream signaling.

Citation

Perayot Pamonsinlapatham, Réda Hadj-Slimane, Yves Lepelletier, Barbara Allain, Mirco Toccafondi, Christiane Garbay, Françoise Raynaud. p120-Ras GTPase activating protein (RasGAP): a multi-interacting protein in downstream signaling. Biochimie. 2009 Mar;91(3):320-8