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1-(11)C]Acetyl chloride ([(11)C]AcCl), an important [(11)C]acylating agent, was synthesized by reacting [(11)C]CO(2) with methylmagnesium bromide coated on the inner surface of a polyethylene loop (loop method). By optimizing the reaction conditions and synthesis parameters, [1-(11)C]phenylacetate and [1-(11)C]benzylacetate were produced from [(11)C]AcCl in high radiochemical yield and specific activity.


Takuya Arai, Ming-Rong Zhang, Masanao Ogawa, Toshimitsu Fukumura, Koichi Kato, Kazutoshi Suzuki. Efficient and reproducible synthesis of [1-11C]acetyl chloride using the loop method. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 2009 Feb;67(2):296-300

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PMID: 19028105

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