Furanocembranoids from the soft corals Sinularia asterolobata and Litophyton arboreum.

The new cembranoid diterpene danielid (1) along with 3alpha-ethoxyfuranocembranoid 2, pukalide (3), 13alpha-acetoxypukalide (4), furanocembranoid 5, and furanosesquiterpene 6 have been isolated from the soft coral Sinularia asterolobata. The furanocembranoid diterpene 11beta,12beta-epoxypukalide (7) and the sesquiterpene (-)-bicyclogermacrene (8) have been obtained from the soft coral Litophyton arboreum. The structures were elucidated primarily by NMR spectroscopy. The furanocembranoids 2, 4, and 5 show good antiproliferative activities against the cell lines L-929 and K-562, and weak cytotoxic effects on HeLa cells.

Citation

Daniela Grote, Hans-Martin Dahse, Karlheinz Seifert. Furanocembranoids from the soft corals Sinularia asterolobata and Litophyton arboreum. Chemistry & biodiversity. 2008 Nov;5(11):2449-56

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PMID: 19035574

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