A one-pot oxidative decarboxylation-Friedel-Crafts reaction of acyclic alpha-amino acid derivatives activated by the combination of iodobenzene diacetate/iodine and iron dust.
Renhua Fan, Weixun Li, Bing Wang
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China. rhfan@fudan.edu.cn
Organic & biomolecular chemistry 2008 Dec 21An efficient one-pot oxidative decarboxylation-Friedel-Crafts reaction of acyclic alpha-amino acid derivatives with electron-rich aromatic compounds is reported. The reaction is activated by the combination of iodobenzene diacetate, iodine and iron dust, resulting in a mild and simple reaction system. The use of iron avoids the oxidation of aromatic compounds, and in situ generation of Fe(III) salts to promote the Friedel-Crafts reaction avoids the use of the highly hygroscopic FeCl(3).
Citation
Renhua Fan, Weixun Li, Bing Wang. A one-pot oxidative decarboxylation-Friedel-Crafts reaction of acyclic alpha-amino acid derivatives activated by the combination of iodobenzene diacetate/iodine and iron dust. Organic & biomolecular chemistry. 2008 Dec 21;6(24):4615-21
Mesh Tags
Substances
PMID: 19039371
View Full Text
