Diverse regulatory mechanisms of eukaryotic transcriptional activation by the proteasome complex.

Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA. sbhaumik@siumed.edu

Critical reviews in biochemistry and molecular biology 2008 Nov-Dec

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The life of any protein within a cell begins with transcriptional activation, and ends with proteolytic degradation. Intriguingly, the 26S proteasome complex, a non-lysosomal protein degradation machine comprising the 20S proteolytic core and 19S regulatory particles, has been implicated in intimate regulation of eukaryotic transcriptional activation through diverse mechanisms in a proteolysis-dependent as well as independent manner. Here, we discuss the intricate mechanisms of such proteasomal regulation of eukaryotic gene activation via multiple pathways.

Citation

Sukesh R Bhaumik, Shivani Malik. Diverse regulatory mechanisms of eukaryotic transcriptional activation by the proteasome complex. Critical reviews in biochemistry and molecular biology. 2008 Nov-Dec;43(6):419-33