Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ.
Lloyd G Czaplewski, Ian Collins, E Andrew Boyd, David Brown, Stephen P East, Mihaly Gardiner, Rowena Fletcher, David J Haydon, Vincent Henstock, Peter Ingram, Clare Jones, Caterina Noula, Leanne Kennison, Chris Rockley, Valerie Rose, Helena B Thomaides-Brears, Rebecca Ure, Mark Whittaker, Neil R Stokes
Prolysis Ltd, Begbroke Science Park, Sandy Lane, Yarnton, Oxfordshire OX5 1PF, UK.
Bioorganic & medicinal chemistry letters 2009 Jan 153-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds.
Citation
Lloyd G Czaplewski, Ian Collins, E Andrew Boyd, David Brown, Stephen P East, Mihaly Gardiner, Rowena Fletcher, David J Haydon, Vincent Henstock, Peter Ingram, Clare Jones, Caterina Noula, Leanne Kennison, Chris Rockley, Valerie Rose, Helena B Thomaides-Brears, Rebecca Ure, Mark Whittaker, Neil R Stokes. Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ. Bioorganic & medicinal chemistry letters. 2009 Jan 15;19(2):524-7
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PMID: 19064318
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