Juliana Leal, Fábio M Squina, Janaína S Freitas, Emiliana M Silva, Carlos J Ono, Nilce M Martinez-Rossi, Antonio Rossi
Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
FEBS letters 2009 Jan 5The Woronin body, a septal pore-associated organelle specific to filamentous ascomycetes, is crucial for preventing cytoplasmic bleeding after hyphal injury. In this study, we show that T1hex-1 transcript and a variant splicing T2hex-1 transcript are up-regulated at alkaline pH. We also show that both hex-1 transcripts are overexpressed in the preg(c), nuc-1(RIP), and pacC(ko) mutant strains of Neurospora crassa grown under conditions of phosphate shortage at alkaline pH, suggesting that hex-1 transcription may be coregulated by these genes. In addition, we present evidence that N. crassa PacC also has metabolic functions at acidic pH.
Juliana Leal, Fábio M Squina, Janaína S Freitas, Emiliana M Silva, Carlos J Ono, Nilce M Martinez-Rossi, Antonio Rossi. A splice variant of the Neurospora crassa hex-1 transcript, which encodes the major protein of the Woronin body, is modulated by extracellular phosphate and pH changes. FEBS letters. 2009 Jan 5;583(1):180-4
PMID: 19071122
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