José Bessa, Laura Carmona, Fernando Casares
Centro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide, Campus UPO, Seville, Spain.
Developmental dynamics : an official publication of the American Association of Anatomists 2009 Janteashirt (tsh) and tiptop (tio) are two Drosophila gene paralogues encoding zinc-finger transcription factors. While tsh is an important developmental regulator, tio null individuals are viable and fertile. Here, we show that tio and tsh have coincident expression domains in the imaginal discs, the precursors of the adult body, and that both genes show similar functional properties when expressed ectopically. Furthermore, tio is able to rescue the development of tsh mutants, indicating that both genes are functionally equivalent during imaginal development. Of interest, the transcriptional regulation of tio and tsh is linked by a negative feedback loop. This mechanism might be required to maintain a tight control on the total levels of tio/tsh and could help explaining why Drosophila keeps an apparently dispensable gene. Copyright (c) 2008 Wiley-Liss, Inc.
José Bessa, Laura Carmona, Fernando Casares. Zinc-finger paralogues tsh and tio are functionally equivalent during imaginal development in Drosophila and maintain their expression levels through auto- and cross-negative feedback loops. Developmental dynamics : an official publication of the American Association of Anatomists. 2009 Jan;238(1):19-28
PMID: 19097089
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