Acetylcholinesterase activity of alkaloids from the leaves of Waltheria brachypetala.

Murilo M C Lima, Jorge A López, Jorge M David, Eliezer P Silva, Ana M Giulietti, Luciano P de Queiroz, Juceni P David

Intituto de Química, Universidade Federal da Bahia, Campus de Ondina, Salvador (BA), Brazil.

Planta medica 2009 Mar

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Chemical investigation of the leaves of Waltheria brachypetala Turks (Sterculiaceae) resulted in the isolation of quinolinone alkaloids, waltherione-A, waltherione-B (N-methylwaltherione-A), 8-methoxyflindersine, and the cyclic peptide alkaloid waltherine. The inhibition of activity of acetylcholinesterase (AChE) by the alkaloids was evaluated. Waltherione-A, waltherione-B and waltherine showed significant activity.

Citation

Murilo M C Lima, Jorge A López, Jorge M David, Eliezer P Silva, Ana M Giulietti, Luciano P de Queiroz, Juceni P David. Acetylcholinesterase activity of alkaloids from the leaves of Waltheria brachypetala. Planta medica. 2009 Mar;75(4):335-7