Regulation of transcription factor activity by SUMO modification.

Jian Ouyang, Alvaro Valin, Grace Gill

Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA, USA.

Methods in molecular biology (Clifton, N.J.) 2009

filter terms:

Post-translational modification by SUMO is an important mechanism to regulate transcription. Sumoyla-tion has diverse effects on substrate activity, but in most cases reported to date sumoylation of transcription factors correlated with transcriptional repression. Here we describe general strategies to address how post-translational modification by SUMO regulates the activity of a DNA-binding transcription factor.

Citation

Jian Ouyang, Alvaro Valin, Grace Gill. Regulation of transcription factor activity by SUMO modification. Methods in molecular biology (Clifton, N.J.). 2009;497:141-52