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Six new ambuic acid (1) derivatives (2-7) and a new torreyanic acid analogue (8) have been isolated from the crude extract of endophytic fungus Pestalotiopsis sp. inhabiting the lichen Multiclavula [corrected] sp. The structures of these compounds were elucidated primarily by NMR and MS methods, and their absolute configurations were assigned by application of the CD excitation chirality method. Compounds 1 and 2 displayed antimicrobial activity against the Gram-positive bacterium Staphylococcus aureus.

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Gang Ding, Yan Li, Shaobin Fu, Shuchun Liu, Jiangchun Wei, Yongsheng Che. Ambuic acid and torreyanic acid derivatives from the endolichenic fungus Pestalotiopsis sp. Journal of natural products. 2009 Jan;72(1):182-6

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PMID: 19117486

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