Negative regulation of Toll-like receptor signaling pathway.

TLRs are primary sensors of invading pathogens, recognizing conserved microbial molecules and activating signaling pathways that are pivotal to innate and adaptive immune responses. However, a TLR signaling pathway must be tightly controlled because its excessive activation can contribute to the pathogenesis of many human diseases. This review provides a summary of the different mechanisms that are involved in the negative regulation of TLR signaling pathways.

Citation

Jie Wang, Yu Hu, Wei Wen Deng, Bing Sun. Negative regulation of Toll-like receptor signaling pathway. Microbes and infection / Institut Pasteur. 2009 Mar;11(3):321-7

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PMID: 19146978

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