Negative regulation of Toll-like receptor signaling pathway.

Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Microbes and infection / Institut Pasteur 2009 Mar

filter terms:

TLRs are primary sensors of invading pathogens, recognizing conserved microbial molecules and activating signaling pathways that are pivotal to innate and adaptive immune responses. However, a TLR signaling pathway must be tightly controlled because its excessive activation can contribute to the pathogenesis of many human diseases. This review provides a summary of the different mechanisms that are involved in the negative regulation of TLR sign aling pathways.

Citation

Jie Wang, Yu Hu, Wei Wen Deng, Bing Sun. Negative regulation of Toll-like receptor signaling pathway. Microbes and infection / Institut Pasteur. 2009 Mar;11(3):321-7