cGMP-dependent protein kinase II and aldosterone secretion.

Beate Spiessberger, Dominik Bernhard, Stefan Herrmann, Susanne Feil, Claudia Werner, Peter B Luppa, Franz Hofmann

Institut für Pharmakologie und Toxikologie, Medizinische Fakultät, Technische Universität München, Germany.

The FEBS journal 2009 Feb

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ACTH-stimulated aldosterone secretion can be inhibited by atrio-natriuretic peptide/cGMP. The mechanism behind this modulation has been reported to involve cGMP-dependent activation of phosphodiesterase 2 (PDE2) and hydrolysis of cAMP. Recently it was reported that activation of cGMP-dependent protein kinase II (cGKII) stimulated aldosterone secretion in rat zona glomerulosa cells. The zona glomerulosa of the murine adrenal cortex expresses cGKII and PDE2. We used mice with a homozygous inactivation of the cGKII gene to investigate in vivo the potential role of this kinase in aldosterone secretion. Basal plasma renin and aldosterone levels were similar in wild-type and cGKII(-/-) mice. In vivo injection of atrio-natriuretic peptide decreased ACTH-stimulated aldosterone secretion in wild-type mice, but had no effect in cGKII-deficient mice. These results support the view that cGKII modulates aldosterone secretion in the murine adrenal cortex.

Citation

Beate Spiessberger, Dominik Bernhard, Stefan Herrmann, Susanne Feil, Claudia Werner, Peter B Luppa, Franz Hofmann. cGMP-dependent protein kinase II and aldosterone secretion. The FEBS journal. 2009 Feb;276(4):1007-13