Chaos begets order: asynchronous cell contractions drive epithelial morphogenesis.

Ewa Paluch, Carl-Philipp Heisenberg

Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Germany.

Developmental cell 2009 Jan

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Apical cell contraction triggers tissue folding and invagination in epithelia. During Drosophila gastrulation, ventral furrow formation was thought to be driven by smooth, purse-string-like constriction of an acto-myosin belt underlying adherens junctions. Now Martin et al. report in Nature that ventral furrow formation is triggered by asynchronous pulsed contractions of the apical acto-myosin cortex in individual cells.

Citation

Ewa Paluch, Carl-Philipp Heisenberg. Chaos begets order: asynchronous cell contractions drive epithelial morphogenesis. Developmental cell. 2009 Jan;16(1):4-6