A versatile approach to beta-amyloid fibril-binding compounds exploiting the Shirakawa/Hayashi protocol for trans-alkene synthesis.

Tri H V Huynh, Mette Louise H Mantel, Katrine Mikkelsen, Anders T Lindhardt, Niels Chr Nielsen, Daniel Otzen, Troels Skrydstrup

Center for Insoluble Protein Structures, Interdisciplinary Nanoscience Center, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.

Organic letters 2009 Feb 19

filter terms:

Application of the Sonogashira coupling reaction followed by a trans-selective alkyne reduction proved highly adaptable for the efficient synthesis of a class of beta-amyloid fibril bind ing compounds possessing a styrylbenzene motif such as FSB, an FSB dimer, and (19)F-BAY94-9172.

Citation

Tri H V Huynh, Mette Louise H Mantel, Katrine Mikkelsen, Anders T Lindhardt, Niels Chr Nielsen, Daniel Otzen, Troels Skrydstrup. A versatile approach to beta-amyloid fibril-binding compounds exploiting the Shirakawa/Hayashi protocol for trans-alkene synthesis. Organic letters. 2009 Feb 19;11(4):999-1002