Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline.

Qian Wu, Joanne M Caine, Stuart A Thomson, Meri Slavica, Gary L Grunewald, Michael J McLeish

Bioorganic & medicinal chemistry letters 2009 Feb 15

filter terms:

Inhibitors of phenylethanolamine N-methyltransferase [PNMT, the enzyme that catalyzes the final step in the biosynthesis of epinephrine (Epi)] may be of use in determining the role of Epi in the central nervous system. Here we describe the synthesis and characterization of 7-SCN tetrahydroisoquinoline as an affinity label for human PNMT.

Citation

Qian Wu, Joanne M Caine, Stuart A Thomson, Meri Slavica, Gary L Grunewald, Michael J McLeish. Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline. Bioorganic & medicinal chemistry letters. 2009 Feb 15;19(4):1071-4