Fetal malformations associated with the use of methylphenobarbital and carbamazepine during pregnancy. Two case reports and review of the literature.

Alenka Aksamija, Dubravko Habek, Milan Stanojević, Boris Ujević

Clinic of Gynecology and Obstetrics, Sveti Duh General Hospital, Zagreb, Croatia.

Fetal diagnosis and therapy 2009

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The use of antiepileptic drugs (AEDs) during pregnancy has been associated with an increased risk of major and minor fetal malformations. This paper describes 2 infants with malformations born to epileptic mothers who used AEDs throughout pregnancy. In the first case, the AED used for seizure control was methylphenobarbital, while in the second case the patient had been prescribed carbamazepine. We noted major and minor congenital malformations in both infants exposed in utero to these anticonvulsant drugs. Pregnant women still experience poor obstetrical care because they report to tertiary centers at the end of their pregnancy or when in labor, making it difficult to provide proper medical care for both the infant and the mother. (c) 2009 S. Karger AG, Basel.

Citation

Alenka Aksamija, Dubravko Habek, Milan Stanojević, Boris Ujević. Fetal malformations associated with the use of methylphenobarbital and carbamazepine during pregnancy. Two case reports and review of the literature. Fetal diagnosis and therapy. 2009;25(1):79-82