Short synthesis and antiviral activity of acyclic phosphonic acid nucleoside analogues.

An efficient route for synthesizing novel allylic and cyclopropanoid phosphonic acid nucleoside analogues is described. The condensation of the bromine derivatives 6 and 18 with nucleoside bases (A, U, T, C, G) under standard nucleophilic substitution and deprotection conditions, afforded the target phosphonic acid nucleoside analogues. These compounds were evaluated for their antiviral properties against various viruses. Cyclopropanoid phosphonic adenine nucleoside analogue 23 showed significant anti-HIV activity.

Citation

Lian Jin Liu, Jin Cheol Yoo, Joon Hee Hong. Short synthesis and antiviral activity of acyclic phosphonic acid nucleoside analogues. Nucleosides, nucleotides & nucleic acids. 2009 Feb;28(2):150-64

Mesh Tags

Substances

PMID: 19219742

search → result