FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease.

Spyros Zissimopoulos, N Lowri Thomas, Wan W Jamaluddin, F Anthony Lai

Wales Heart Research Institute, Department of Medicine-Cardiology, Cardiff University School of Medicine, Cardiff CF14 4XN, Wales, UK. zissimopouloss@cf.ac.uk

The Biochemical journal 2009 Apr 15

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In the present paper we show that distinct human RyR2 (ryanodine receptor type 2) inherited mutations expressed in mammalian cells exhibit either unaltered or increased FKBP12.6 (12.6 kDa FK506-binding protein) binding compared with the wild-type. Oxidizing conditions result in decreased FKBP12.6 binding, but to the same extent as for the wild-type. Our findings suggest that FKBP12.6 regulation of RyR2 is unlikely to be the primary defect in inherited arrhythmogenic cardiac disease.

Citation

Spyros Zissimopoulos, N Lowri Thomas, Wan W Jamaluddin, F Anthony Lai. FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease. The Biochemical journal. 2009 Apr 15;419(2):273-8