Swietenine: a potential oral hypoglycemic from Swietenia macrophylla seed.

Saikat Dewanjee, Anup Maiti, Anup K Das, Subhash C Mandal, Sankar P Dey

Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. s.dewanjee@yahoo.com

Fitoterapia 2009 Jun

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Swietenine, a tetranortriterpenoid, was isolated from the Swietenia macrophylla seeds. The in vivo hypoglycemic activity was evaluated against neonatal-streptozotocin induced type 2 diabetic rats. Oral administration of swietenine at 25 and 50 mg/kg body weight per day to diabetic rats was found to possess significant dose dependant hypoglycemic and hypolipidemic activity in type 2 diabetic rats.

Citation

Saikat Dewanjee, Anup Maiti, Anup K Das, Subhash C Mandal, Sankar P Dey. Swietenine: a potential oral hypoglycemic from Swietenia macrophylla seed. Fitoterapia. 2009 Jun;80(4):249-51