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The serine/threonine kinase Akt is a focal point in signaling pathways that control cell tumorigenesis and insulin resistance. In this issue, Padmanabhan et al. (2009) identify a phosphatase regulatory subunit PPTR-1 that regulates the insulin/insulin-like growth factor 1 pathway by counteracting Akt activity in worms and mammalian cells.
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Reuben Shaw, Andrew Dillin. PPTR-1 counterAkts insulin signaling. Cell. 2009 Mar 6;136(5):816-8
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PMID: 19269361
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