Ectodysplasin signaling in cutaneous appendage development: dose, duration, and diversity.

Division of Developmental Biology, Roslin Institute and R(D)SVS, University of Edinburgh, Midlothian, United Kingdom. denis.headon@roslin.ed.ac.uk

The Journal of investigative dermatology 2009 Apr

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The development of several types of skin appendages is guided by prenatal ectodysplasin signaling. In this issue, Cui et al. report on the dose and duration of ectodysplasin signaling required for the maintenance and morphogenesis of different types of appendages. They report that achievement of an intimate arrangement between epithelial and mesenchymal cell populations correlates with the acquisition of autonomy from ectodysplasin stimulation.

Citation

Denis J Headon. Ectodysplasin signaling in cutaneous appendage development: dose, duration, and diversity. The Journal of investigative dermatology. 2009 Apr;129(4):817-9