Spermatogenesis associated retrogenes are expressed in the human ovary and ovarian cancers.

Jan Rohozinski, Matthew L Anderson, Russell E Broaddus, Creighton L Edwards, Colin E Bishop

PloS one 2009

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Ovarian cancer is the second most prevalent gynecologic cancer in women. However, it is by far the most lethal. This is generally attributed to the absence of easily detectable markers specific to ovarian cancers that can be used for early diagnosis and specific therapeutic targets. Using end point PCR we have found that a family of retrogenes, previously thought to be expressed only in the male testis during spermatogenesis in man, are also expressed in normal ovarian tissue and a large percentage of ovarian cancers. In man there are at least eleven such autosomal retrogenes, which are intronless copies of genes on the X chromosome, essential for normal spermatogenesis and expressed specifically in the human testis. We tested for the expression of five of the known retrogenes, UTP14C, PGK2, RPL10L, RPL39L and UBL4B in normal human ovary and ovarian cancers. We propose that the activation of the testis specific retrogenes in the ovary and ovarian cancers is of biological significance in humans. Because these retrogenes are specifically expressed in the ovary and ovarian cancers in the female they may prove useful in developing new diagnostic and/or therapeutic targets for ovarian cancer.

Citation

Jan Rohozinski, Matthew L Anderson, Russell E Broaddus, Creighton L Edwards, Colin E Bishop. Spermatogenesis associated retrogenes are expressed in the human ovary and ovarian cancers. PloS one. 2009;4(3):e5064